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Schematic presentation of viral constructs. Non-replicative, E1/E3-deleted Ad5TK-GFP contains the TK-GFP fusion gene. Both replicative viruses (Ad5 Δ24TK-GFP and Ad5 Δ24) feature a 24-bp deletion in the Rb binding site of E1A. Additionally, in Ad5 Δ24TK-GFP E3 region is replaced with TK-GFP, which is driven by CMV promoter. Ψ, packaging signal; ITR, inverted terminal repeat; TK, thymidine kinase; CMV, cytomegalovirus promoter.
