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. Author manuscript; available in PMC: 2008 Jan 16.
Published in final edited form as: Int J Mol Med. 2006 Oct;18(4):751–759.

Figure 5.

Figure 5

Efficacy of Ad5 Δ24TK-GFP in vivo. Ad5TK-GFP, Ad5 Δ24TK-GFP and Ad5 Δ24 viruses were injected intratumorally to subcutaneous SKOV3.ip1 tumors. (A) Animals received either saline (■) or GCV (□) intraperitoneally for 12 days starting 1 day after virus injections. After ganciclovir treatment animals were euthanized and tumors were weighted. Both replicative viruses significantly reduced tumor growth compared to Ad5TK-GFP treatment only, but GCV did not significantly increase the cell killing. ***p<0.001 compared to AdTK-GFP only treated cells. Error bars indicate standard error of the mean (B) For monitoring viral spreading, Ad5TK-GFP (■) and Ad5 Δ24TK-GFP (□) infected tumor cells were analyzed by flow cytometry at different time points. *p<0.05 Ad5TK-GFP vs. Ad5 Δ24TK-GFP. Error bars indicate standard error of the mean.