Table 2.

Characteristics of study patients [median (range)] and plasma samples.

Demographic data
Number of patients	30
Sex	18 male, 12 female
Age (years)	25 (16–61)
Weight (kg)	57 (46–86)
Height (cm)	169 (149–186)
Lean body weight (kg)*	46 (36–64)
Number of comedications per patient	13 (7–21)
Pharmacokinetic data
Number of total blood samples	241
Number of blood samples per patient	8
Itraconazole concentrations (mg l−1), range	0.04–0.77
Number of itraconazole concentrations	111 (46.0%)
below LOD (LOD = 0.040 mg l−1)
Capsules	81 (33.6%)
Solution	30 (12.4%)
Hydroxy-itraconazole concentrations (mg l−1), range	0.04–0.86
Number of hydroxy-itraconazole concentrations below LOD (LOD = 0.040 mg l−1)	67 (27.8%)
Capsules	50 (20.8%)
Solution	17 (7.0%)

^*Calculated as per Cheymol [34]. LOD, Limit of detection.