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Peak concentrations in plasma (Cmax) and time to Cmax (tmax), AUC0–∞ determined from the posterior Bayes estimates parameter estimates from NONMEM. Reported as median (range) and 90% confidence intervals (CI)
| Cmax (mg l−1) | tmax (h) | AUC0–∞ (mg h−1 l−1) | Frel (AUCcap/AUCsol) | |
|---|---|---|---|---|
| Capsules | 0.064 (0.018–0.23) | 4.15 (1.78–105.31) | 4.42 (2.15–23.81) | 0.76 (range 0.30–3.40) (CI 0.36, 1.97) |
| Solution | 0.23 (0.038–1.094) | 1.94 (0.85–20.86) | 6.32 (3.76–8.47) |
