Table 1.

Maximum collagen-stimulated platelet aggregation and bleeding time in healthy male subjects 4 h after administration of naproxen 500 mg alone, rivaroxaban 15 mg alone, or rivaroxaban 15 mg and naproxen 500 mg given together (n = 11)

Parameter	Rivaroxaban minus naproxen	Rivaroxaban + naproxen minus naproxen	Rivaroxaban minus rivaroxaban + naproxen
Collagen-stimulated platelet aggregation,%	67.4* (40.0, 94.8)	4.72ns (−17.2, 26.6)	62.7* (35.6, 89.8)
Bleeding time, min	−1.81ns (−3.91, 0.30)	3.43** (2.36, 4.50)	−5.24* (−7.73, −2.75)

Values are means (95% confidence interval). For differences between groups: ns, not significant;

^*P < 0.001;

^**P < 0.0001.