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Pharmacokinetics of rivaroxaban (15 mg) given alone and with naproxen (500 mg) to 11 healthy subjects
| Parameter | Rivaroxaban | Rivaroxaban + naproxen |
|---|---|---|
| AUC, µg·h l−1 | 1250 (28.6) | 1396 (26.3) |
| AUCnorm, g·h l−1 | 6740 (35.8) | 7526 (31.7) |
| Cmax, µg l−1 | 152.9 (31.5) | 165.3 (27.7) |
| Cmax,norm, g l−1 | 824.5 (36.5) | 891.0 (33.9) |
| t1/2, h | 8.59 (29.0) | 7.85 (24.6) |
| tmax*, h | 1.0 (1.0–3.0) | 2.0 (0.5–4.0) |
Median value (range). Values are means (coefficient of variation).
