Table 2.
Pharmacokinetic results of tenofovir, with or without coadministration of TMC114 and ritonavir (TMC114/r)
| Pharmacokinetic parameter | Without TMC114/r | With TMC114/r | LS mean ratio (90% CI) | P-value |
|---|---|---|---|---|
| Mean ± SD | ||||
| n | 12 | 12* | – | – |
| C0 h, ng ml−1 | 67.4 ± 14.3 | 88.9 ± 17.0 | 1.36 (1.17, 1.58) | 0.003 |
| Cmin, ng ml−1 | 65.6 ± 13.4 | 86.8 ± 15.7 | 1.37 (1.19, 1.57) | 0.001 |
| Cmax, ng ml−1 | 423 ± 75.2 | 528 ± 106 | 1.24 (1.08, 1.42) | 0.01 |
| AUC24 h, ng h−1 ml−1 | 3789 ± 499 | 4633 ± 735 | 1.22 (1.10, 1.35) | 0.003 |
| Median (range) | ||||
| Tmax, h | 1.5 (0.5–2.5) | 1.0 (1.0–4.0) | – | 0.74 |
CI, Confidence interval; LS, least square; n, number of volunteers; SD, standard deviation.
*
n = 11 for C0 h and Cmin.