Table 3.
Haematological toxicity according to World Health Organization toxicity criteria
| Toxicity | Cohort I | Cohort II | Cohort III | Cohort IV | Cohort V | P-value for trend* |
|---|---|---|---|---|---|---|
| Anemia | 0.02 | |||||
| Grade I/II | 13 | 8 | 2 | 1 | ||
| Grade III/IV | 10 | 12 | 2 | 4 | 3 | |
| Leucocytopenia | <0.01 | |||||
| Grade I/II | 7 | 12 | 3 | 2 | 1 | |
| Grade III/IV | 4 | 8 | 1 | 2 | 3 | |
| Neutropenia | 0.06 | |||||
| Grade I/II | 4 | 9 | 2 | 1 | ||
| Grade III/IV | 9 | 11 | 2 | 4 | 3 | |
| Thrombocytopenia | 0.01 | |||||
| Grade I/II | 7 | 11 | 1 | 3 | ||
| Grade III/IV | 1 | 3 | 1 | 4 | ||
| Mean HB nadir (SE) | 8.5 (0.13) | 8.3 (0.46) | 8.4 (1.54) | 6.0 (0.31) | 7.0 (0.38) | 0.02 |
| Mean WBC nadir (SE) | 4.2 (0.45) | 2.2 (0.20) | 2.4 (0.37) | 1.5 (0.47) | 1.6 (0.65) | <0.01 |
| Mean ANC nadir (SE) | 1.9 (0.31) | 0.9 (0.15) | 0.9 (0.36) | 0.3 (0.19) | 0.5 (0.25) | 0.05 |
| Mean PLT nadir (SE) | 233 (29) | 145 (14) | 222 (38) | 85 (30) | 111 (17) | 0.02 |
HB, Haemoglobin (g dl−1); WBC, white blood cell count (103 µl−1); ANC, absolute neurophil count (103 µl−1); PLT, platelets (106 µl−1); SE, standard error.
*
Using the Kruskal–Wallis test.