Table 4.
Nonhaematological toxicity according to World Health Organization toxicity criteria (excluding fatigue, alopecia, nausea/vomiting)
| Toxicity | Cohort I | Cohort II | Cohort III | Cohort IV | Cohort V | P-value for trend* |
|---|---|---|---|---|---|---|
| Diarrhoea | 0.34 | |||||
| Grade I | 5 | 2 | ||||
| Grade III | 1 | 1 | ||||
| Mucositis | 0.04 | |||||
| Grade I/II | 2 | |||||
| Grade III | 1 | 1 | ||||
| Myalgia/arthralgia | 0.71 | |||||
| Grade I/II | 11 | 8 | 1 | |||
| Grade III | 1 | |||||
| Allergic reactions | 0.27 | |||||
| Grade I/II | 2 | 2 | 1 | |||
| Grade III | 1 | |||||
| Sensory polyneuropathy | 0.70 | |||||
| Grade I | 7 | 7 | 2 | |||
| Grade II | 3 | 2 | 1 | |||
| Neutropenic fever | <0.01 | |||||
| Grade III | 4 | 2 | 3 | |||
| Grade IV | 1 | 1 |
*
Using the Kruskal–Wallis test.