Table 3.
Type of covariate tested and selected in the 251 (out of 360) PK models and in the 43 (out of 118) PD models when a covariate model is performed. For each method, we report the number of models and in brackets, the percentage referring to the corresponding category
| PK models | PD models | |||||||
|---|---|---|---|---|---|---|---|---|
| Covariate models | 251 (69.7) | 43 (36.4) | ||||||
| Covariates | Tested* | Kept* | Tested* | Kept* | ||||
| Demographic | 233 | (92.8) | 186 | (74.1) | 31 | (72.1) | 10 | (23.3) |
| Liver/Kidney function | 122 | (48.6) | 105 | (41.8) | 12 | (27.9) | 8 | (18.6) |
| Biological parameter | 41 | (16.3) | 34 | (13.6) | 7 | (16.3) | 6 | (14.0) |
| Drug interaction | 58 | (23.1) | 47 | (18.7) | 9 | (20.9) | 3 | (7.0) |
| Dose | 33 | (13.1) | 26 | (10.4) | 4 | (9.3) | 3 | (7.0) |
| Metabolism induction/inhibition | 24 | (9.6) | 19 | (7.6) | 3 | (7.0) | 2 | (4.7) |
| Disease | 45 | (17.9) | 37 | (14.7) | 12 | (27.9) | 6 | (14.0) |
| Food | 14 | (5.6) | 13 | (5.2) | ||||
| Performance status | 21 | (8.4) | 18 | (7.2) | 2 | (4.7) | 1 | (2.3) |
| Time | 22 | (8.8) | 17 | (6.8) | 3 | (7.0) | 2 | (4.7) |
| Administration | 10 | (4.0) | 10 | (4.0) | 6 | (14.0) | 3 | (7.0) |
| Adverse events | 1 | (0.4) | 0 | (0.0) | ||||
| PK parameters | 4 | (9.3) | 3 | (7.0) | ||||
*
Under each category, the percentages in one column sum up to more than 100% because several different covariates could be tested and kept in the same model.