Figure 1.

Sequence and structure of 10FnIII. (A) Sequence of 10FnIII. Residues that are part of the β-strand framework are in bold. Residue positions that were selected for randomization are colored red. (B) Two structural views of 10FnIII. The crystal structure of the 10FnIII domain shown is part of the 7–10FnIII domains (left, PDB accession no. 1FNF). The randomized BC and FG loop regions are colored red. The first seven N-terminal residues are colored green. The solution structure of 10FnIII is illustrated in a side view without the unstructured N-terminal residues (right, PDB accession no. 1TTG).