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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: Cell Signal. 2007 Apr 20;19(7):1372–1382. doi: 10.1016/j.cellsig.2007.03.013

Figure 4. Regulation of MKP-1 expression by immunomodulatory agents.

Figure 4

Anti-inflammatory/immunosuppressive agents, such as glucocorticoids, IL-10, and glutamine, induce/augment MKP-1 expression, leading to inhibition of the p38 and JNK cascades and attenuation of inflammatory response. In contrast, pro-inflammatory cytokines, such as IFN-γ and MIF, inhibit MKP-1 expression, thereby perpetuating the p38 and JNK signalling pathways and enhancing the inflammatory response.