Table 3.
Enriched categories – genes significantly up- or down-regulated at 8 months (but not significant at 3 or 5 months)
| Enriched Category (p-value) | Subcategory | Examples | 3 mo | 5 mo | 8 mo |
| (-fold change) | |||||
| Purine Nucleotide (p < 0.00025) | Kinases | av-yes homolog | -1.1 | 1.5 | 2.7 |
| CaM kinase-4 | 1.2 | -1.1 | 2.5 | ||
| B-Raf | 1.1 | 1.1 | 2.3 | ||
| DAP-kinase 1 | -1.2 | 1.3 | 2.1 | ||
| bUhm Kinase 1 | 1.0 | -1.3 | -2.5 | ||
| GTPases | RhoC | 1.3 | 1.5 | 2.4 | |
| Era1 | 1.8 | -1.1 | 2.3 | ||
| aGimap4 | 2.2 | 1.1 | 2.3 | ||
| Receptors | EDG3 | 1.9 | 2.2 | 2.5 | |
| bEphRa3 | 1.7 | -1.0 | -2.7 | ||
| Transporters | aABC1 | 1.7 | 1.9 | 2.3 | |
| bABCA8a | -1.6 | -1.2 | -2.1 | ||
| Kinesins | Kinesin 18a | -1.2 | 1.7 | 2.1 | |
| bKinesin 5a/c | 1.0 | -1.3 | -2.0 | ||
| Negative Regulators Of Cellular Processes (p < 0.0037) | Transcription Factors | a,bC/EBP-β | 1.3 | 1.4 | 2.6 |
| a,bC/EBP-α | 1.1 | 1.4 | 2.2 | ||
| aKruppel-like 4 | 1.3 | 1.8 | 2.1 | ||
| Midline | -1.9 | -1.5 | -2.2 | ||
| bHes5 | 1.2 | -1.1 | -3.3 | ||
| Growth Factors | aIGF-1 | 1.6 | 1.6 | 3.2 | |
| a,bCNTF | 1.4 | 1.5 | 2.8 | ||
| Signaling | aRGS-1 | 1.2 | 2.0 | 5.0 | |
| RGS-2 | 1.2 | 1.0 | 2.2 | ||
| bAA 8 lipoxygenase | -1.5 | -1.1 | -2.2 | ||
| Intracellular Transport (p < 0.013) | Proton/Solute Carriers | a,bUCP2 | -1.8 | -1.0 | 3.2 |
| Slc1a3 (glial) | -1.3 | 1.2 | 2.6 | ||
| Nuclear Transport | Nucleoporin214 | -1.0 | 1.1 | 2.6 | |
| Ipoll | -1.0 | -1.0 | 2.4 | ||
| Positive Regulators Of Cellular Processes (p < 0.018) | Transcription Factors | bAtonal homolog-1 | -2.0 | 1.3 | -2.4 |
| aNFAT5 | 1.2 | 1.1 | -2.8 | ||
| Cell Adhesion (p < 0.018) | Cell surface | aICAM | 1.8 | 2.5 | 5.4 |
| aCD44 | 1.2 | 2.4 | 4.5 | ||
| Annexin A9 | 1.7 | 1.2 | 3.0 | ||
| Extracellular matrix | Procollagen ivα5 | 1.2 | 1.7 | 2.9 | |
| Transglutaminase 2c | 1.4 | 1.6 | 2.2 | ||
aReported to be highly expressed in immune cells
bReported to be highly expressed in neuronal cells