Table 3.
Genes differentially expressed during ES cell differentiation in serum versus serum-free defined media (BMP4 2 ng/ml)
| Set 1 – Chemokine ligands (Day 8) | Symbol | Synonyms | Genbank ID | BMP4 | Serum |
| Hydroxyprostaglandin dehydrogenase 15 | Hpgd | NM_008278.1 | 2.22 | 4.4 | |
| Src-like adaptor | Sla | Slap | NM_009192 | 1.29 | .90 |
| Pleckstrin | Plek | NM_019549.1 | 1.31 | 4.9 | |
| Triggering receptor expressed on myeloid cells-like 1 | Treml1 | XM_128641.3 | 1.67 | 12.6 | |
| Glycoprotein 5 (platelet) | Gp5 | GPV | NM_008148.2 | 1.52 | 8.9 |
| 2810484G07Rik | 2.07 | 13.5 | |||
| Chemokine (C-X-C motif) ligand 7 | Cxcl7 | b-TG1; CTAP3; LDGF; MDGF;NAP-2 | NM_023785.1 | 1.07 | 4.8 |
| Angiotensin receptor 1 | Agtr1 | AT1;AT1a;AT2R1 | NM_177322.2 | 1.58 | 5.8 |
| Arachidonate 12-lipoxygenase | Alox12 | Alox12p;P-12LO | NM_007440.2 | 1.29 | 9.2 |
| Chemokine (C-C motif) ligand 4 | Ccl4 | Act-2; MIP-1B | NM_013652 | 1.81 | 19.5 |
| Chemokine (C-X-C motif) ligand 4 | Cxcl4 | Pf4;Scyb4 | NM_019932.1 | 3.85 | 29.0 |
| ATPase, Ca2+ transporting, ubiquitous | Atp2a3 | Serca3 | NM_016745.2 | 1.30 | 6.1 |
| Chemokine (C-C motif) ligand 3 | Ccl3 | Mip1a;Scya3 | NM_011337.1 | 1.75 | 11.8 |
| Set 2 – Globins (Day 6) | Symbol | Synonyms | Genbank ID | BMP4 | Serum |
| β-major globin | Hbb-b1 | AK002258 | 2.15 | 21.7 | |
| ζ-globin | Hba-x | NM_010405.2 | 4.30 | 128.3 | |
| ε-y globin | Hbb-y | E-y | NM_008221.2 | 1.80 | 38.1 |
| Nuclear factor erythroid-2 (p45) | Nfe2 | p45NFE2 | NM_008685.2 | 1.32 | 10.4 |
| α-globin | Hba-a1 | Hba1 | NM_008218.1 | 3.21 | 89.7 |
| Band-3/anion exchanger 1 | Slc4a1 | Ae1;CD233;Band 3 | NM_011403.1 | 1.19 | 26.2 |
| Rik2510042H12 | AK011092 | 1.01 | 4.1 | ||
| Aminolevulinic acid synthase 2 | Alas2 | Alas-2 | NM_009653.1 | 1.14 | 13.2 |
| β h1-globin | Hbb-bh1 | betaH1 | NM_008219.2 | 3.65 | 61.2 |
| Set 3 – Blood (Day 8) | Symbol | Synonyms | Genbank ID | BMP4 | Serum |
| Alpha hemoglobin stabilising protein | AHSP | AHSP;EDRF | NM_133245.1 | 1.7 | 3.4 |
| Myeloperoxidase | Mpo | NM_010824 | 1.1 | 3.6 | |
| Slc38a5 | SN2; JM24 | NM_172479.1 | 1.3 | 2.5 | |
| Glycophorin A | Gypa | CD235a;GPA | NM_010369.2 | 2.1 | 5.2 |
| Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | Cited4 | Mrg2 | NM_019563 | 1.3 | 2.5 |
| Mitoferrin | Mscp | Slc25a37 | NM_030054.2 | 1.5 | 2.4 |
| Kruppel-like factor 1 | Klf1 | Eklf | NM_010635 | 1.8 | 3.6 |
| Set 4 – Various (Day 16) | Symbol | Synonyms | Genbank ID | BMP4 | Serum |
| FXYD domain-containing ion transport regulator 2 | Fxyd2 | Atp1g1 | NM_007503 | 1.38 | 6.7 |
| Thioether S-methyltransferase | Temt | NM_009349 | 0.97 | 6.0 | |
| Mus musculus FXYD domain-containing ion transport regulator 2, transcript variant a | Fxyd2 | Atp1g1 | NM_052824.1 | 1.16 | 5.7 |
| Fibrinogen, alpha | Fga | Fib | NM_010196.1 | 2.06 | 11.8 |
| Kininogen-1 | Kng1 | NM_023125.2 | 6.25 | 37.3 | |
| Serum amyloid A 3 | Saa3 | Saa-3 | NM_011315 | 1.04 | 4.5 |
| Deleted in azoospermia-like | Dazl | Dazla;Tpx-2;Tpx2 | NM_010021.2 | 0.91 | 3.8 |
| Fibrinogen, alpha | Fga | Fib | NM_010196.1 | 2.57 | 14.3 |
| Chitinase 3-like 1 | Chi3l1 | brp-39;Brp39;Gp39 | NM_007695.1 | 1.75 | 7.3 |
| Kininogen II | NM_201375.1 | 1.73 | 7.9 | ||
| Set 5 – Macrophage (Day 16) | Symbol | Synonyms | Genbank ID | BMP4 | Serum |
| Neutrophil cytosolic factor 2 | Ncf2 | Ncf-2; p67phox | NM_010877 | 2.05 | 3.56 |
| Complement component 1q beta | C1qb | NM_009777.1 | 1.13 | 4.63 | |
| Matrix metalloproteinase 12 | Mmp12 | Mmel | NM_008605.1 | 3.17 | 8.53 |
| Complement component 3 | C3 | ASP;Plp | NM_009778.1 | 2.17 | 10.46 |
| CD68 antigen | Cd68 | gp110;Scard1 | NM_009853 | 1.84 | 5.58 |
| Macrophage expressed gene 1 | Mpeg1 | XM_129176 | 3.08 | 6.74 | |
| TYRO protein tyrosine kinase binding protein | Tyrobp | DAP12;KARAP;Ly83 | NM_011662.2 | 2.80 | 4.81 |
| Myosin IF | Myo1f | NM_053214.1 | 1.64 | 3.33 | |
| Hematopoietic protein 1 | Hemp1 | NM_153505.2 | 1.41 | 4.22 | |
| Glutathione S-transferase, alpha 3 | Gsta3 | Gst2-3 | NM_010356.2 | 1.73 | 8.67 |
| Glycoprotein (transmembrane) nmb | Gpnmb | Dchil;ipd | NM_053110 | 1.55 | 6.63 |
| Pleckstrin homology, Sec7 and coiled/coil domains 4 | Pscd4 | 2510004M07Rik | NM_028195 | 1.54 | 3.83 |
| B-cell leukaemia/lymphoma-2 related protein A1b | Bcl2a1b | A1-b | NM_007534 | 2.49 | 6.35 |
| Complement component 1q, gamma | C1qg | C1qc | NM_007574.1 | 1.26 | 5.27 |
| Fc receptor, IgG, low affinity III | Fcgr3 | CD16 | NM_010188.2 | 2.10 | 5.84 |
| Lysozyme | Lyzs | Lys;Lzm;;Lzp | NM_017372.2 | 5.80 | 21.72 |
| Chemokine (C-C motif) ligand 9 | Ccl9 | CCF18;MRP-2; | NM_011338 | 2.26 | 3.85 |
| B-cell leukemia 2 related protein A1d | Bcl2a1d | A1-d | NM_007536 | 2.51 | 4.49 |
| EGF-like module containing, mucin-like, hormone receptor-like 1 | Emr1 | F4/80; Ly71;TM7LN3 | NM_010130.1 | 1.54 | 3.44 |
| Set 6 – Day 16 | Symobol | Synonyms | Genebank ID | BMP4 | Serum |
| Insulin-like growth factor 1 | Igf1 | C730016P09Rik;Igf-1;Igf-I | NM_010512.2 | 1.6 | 4.8 |
| Prss35 | NM_178738.1 | 4.7 | 5.9 | ||
| Protein tyrosine phosphatase, non-receptor type substrate 1 | Ptpns1 | CD172a; SHP-1;SHPS-1; | XM_149178.1 | 2.2 | 3.7 |
| Apolipoprotein A-II | Apoa2 | Alp-2;Apoa-2;ApoA-II;Hdl-1 | NM_013474.1 | 9.8 | 57.4 |
| Spondin 2, extracellular matrix protein | Spon2 | ;M-spondin;Mindin | NM_133903.2 | 2.0 | 12.0 |
| Set 7 – Stem and late Day 16 | Symbol | Synonyms | Genbank ID | BMP4 | Serum |
| Fbox 15 | Fbxo15 | 0.96 | 4.4 | ||
| Aurora kinase C | Aurkc | AIE1;AIK3;Stk13 | NM_020572.1 | 0.94 | 4.1 |
| 2200001I15Rik | NM_183278.1 | 0.94 | 6.4 | ||
| Hypothetical protein LOC236546 | AF067061 | NM_199060.1 | 0.85 | 3.8 | |
| Eukaryotic translation initiation factor 1A | LOC195150 | XM_111306.1 | 0.80 | 9.3 | |
| Similar to Pro-Pol-dUTPase polyprotein; RNaseH | LOC386244 | XM_359136.1 | 0.88 | 5.2 | |
| Similar to hypothetical protein FLJ35105 | LOC245109 | XM_142517.3 | 0.89 | 3.7 | |
| Down regulated in renal cell carcinoma | Drr1 | TU3A | AK044219 | 0.57 | 9.3 |
| Set 8 – Cardiac Day 16 | Symbol | Synonyms | Genbank ID | BMP4 | Serum |
| ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | Atp2a1 | SERCA1 | NM_007504.2 | 6.9 | 1.1 |
| Cholinergic receptor, nicotinic, gamma | Chrng | Achr-3;Acrg | NM_009604.2 | 4.5 | 1.0 |
| Myosin, light polypeptide 1 | BC059087.1 | 8.0 | 1.1 | ||
| Alpha actin, skeletal muscle | Acta1 | Acta-2;Acts;Actsk-1 | NM_009606.1 | 25.3 | 1.2 |
| Tropomyosin 2 beta | Tpm2 | Tpm-2;Trop-2 | NM_009416.2 | 11.6 | 1.3 |
| Cholinergic receptor, nicotinic, alpha | Chrna1 | Achr-1;Acra | NM_007389.2 | 4.1 | 1.0 |
| Troponin C2, fast | Tnnc2 | Tncs | NM_009394.2 | 5.7 | 0.9 |
| Neurofilament 3, medium | Nef3 | NF-M;NF160;Nfm | NM_008691.1 | 4.5 | 1.1 |
| Myosin heavy chain | Myh8 | XM_354617 | 6.7 | 1.1 | |
| Cholinergic receptor, nicotinic, alpha 1 | Chrna1 | Achr-1;Acra | NM_007389.2 | 5.4 | 1.1 |
| Set 9 – Cardiac 2 Day 6 | Symbol | Synonyms | Genbank ID | BMP4 | Serum |
| a-Actin, cardiac | Actc1 | Actc-1 | NM_009608.1 | 31.2 | 3.6 |
| Somatostatin | Sst | Smst;SOM;SRIF;SS | NM_009215.1 | 10.8 | 2.2 |
| Myosin, light polypeptide 7, regulatory | Myl7 | MLC2a;MYL2A;;RLC-A | NM_022879.1 | 14.3 | 4.7 |
| Myosin, heavy polypeptide 7, cardiac muscle, beta | Myh7 | Myhc-b;Myhcb | NM_080728.1 | 8.2 | 2.4 |
| a-Actin, cardiac | Actc1 | Actc-1 | NM_009608.1 | 26.3 | 3.5 |