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. 2008 Jan 10;57(1):41–55. doi: 10.1016/j.neuron.2007.11.018

Figure 1.

Figure 1

Identification of Olfactory miRNAs by Microarray and Cloning Approaches

(A) Hierarchical clustering of miRNA expression profiles from several tissues using microRNA microarrays (Miska et al., 2004). The cluster of miRNAs with predicted enrichment in olfactory tissues is highlighted (right panel). Blue color indicates weak hybridization signals, and yellow indicates strong hybridization signals. miRNAs are considered present in a given tissue if they display a normalized signal intensity (NSI) ≥ 100.

(B and C) Validation by northern blot analysis of miRNAs identified by microarray and cloning strategies. All tissue samples originate from adult mice (P60), excluding rat VNO (P60) and rat MOE (P1). miR-122a, known to be exclusively expressed in liver tissue, is used as a positive control. U6 snRNA serves as a loading control.