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. 2008 Jan 10;57(1):41–55. doi: 10.1016/j.neuron.2007.11.018

Figure 2.

Figure 2

Expression Patterns of Olfactory miRNAs Analyzed by Locked Nucleic Acid-Based In Situ Hybridization

(A) Three basic patterns of miRNA expression were identified during embryonic MOE development. Left: the expression of miR-34b, 34c, 139, 205, and 449 is restricted to the respiratory epithelium. Middle: the expression of miR-125b, 140∗, 199a, 199a∗, and 199b is restricted to the mesenchyme underlying or cartilage surrounding the MOE. Right: the expression of miR-96, 141, 182, 183, 200a, 200b, 191, and 429 is strongest in the MOE and VNO neuroepithelium, with reduced levels in the respiratory epithelium. OE, olfactory epithelium; RE, respiratory epithelium; VNO, vomeronasal organ.

(B) Developmental time course analysis of miR-200 family member expression.

(C) Genomic organization of mouse miR-200 family members.