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. 2008 Jan 30;3(1):e1493. doi: 10.1371/journal.pone.0001493

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Thompson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Number of parasites per mL, estimated using a calibration curve, plotted by day post sporozoite challenge. A. Three volunteers selected to demonstrate expected pattern of PCR results: an exponential increase in the numbers of parasites over time, with some cycling seen as parasites are sequestered and released. B. This figure shows data from all 4 volunteers who had unusual PCR results. Up to 150 parasites/mL are detected, and are subsequently undetectable for one or more time points, before they are measured again. This pattern occurs several times, up to a maximum of 5 times in volunteer N525.