TABLE 3.
RESULTS OF MULTIVARIATE COX REGRESSION ANALYSIS TO PREDICT TIME TO FIRST EXACERBATION BASED ON 6-MONTH CHANGE IN PHYSIOLOGIC VARIABLES AMONG SURGICAL PATIENTS
| Variable* | Hazard Ratio | P Value |
|---|---|---|
| ΔFEV1 (10 ml) | 3.2 | 0.002 |
| Δ Slow VC (10 ml) | 1.13 | 0.28 |
| ΔRV (10 ml) | 1.02 | 0.33 |
| ΔFRC (10 ml) | 1.01 | 0.59 |
| Δ Maximal work (1 W) | 1.00 | 0.40 |
| ΔPaO2 (1 mm Hg) | 1.01 | 0.33 |
| ΔPaCO2 (1 mm Hg) | 1.01 | 0.79 |
| ΔMEP (1 cm H2O) | 1.00 | 0.73 |
Definition of abbreviation: MEP = maximal expiratory pressure.
Increments of each covariate used for calculation of the hazard Ratio are provided in parentheses after the named covariate in the first column.
*
Each of the covariates was calculated at the absolute change in value between the 6-month postoperative measurement and baseline, prerandomization values (i.e., 6-mo FEV1 in L – FEV1 in L measured before randomization).