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. Author manuscript; available in PMC: 2008 Jan 17.
Published in final edited form as: Cereb Cortex. 2006 Jul 3;17(5):1235–1240. doi: 10.1093/cercor/bhl034

Figure 4.

Figure 4

The excitatory effect of the D2 agonist is observed only in slices from adult animals. (A) Scatter plot showing the effect of quinpirole on PFC interneurons excitability from prepubertal to adult ages, expressed as the ratio between evoked firing after and before quinpirole administration. Open circles are individual neurons recorded from each group, and the data were grouped into age ranges. The excitatory effect of quinpirole (1 μM) was observed only in developmentally mature rats. (B) Bar graph (mean ± SD) summarizing the effect of quinpirole on prepubertal PFC interneurons (PD < 36) and those observed in the PFC of adult (PD > 50) animals (***P < 0.0001, repeated measures ANOVA).