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Comparison of ligand-induced FGFR responses
| Receptor/Effector | Cells
|
|||||
|---|---|---|---|---|---|---|
| L6/3T3 | L6/BaF3 | L6E9 | L6 | L6 | PC12 | |
| FGFR1 | ||||||
| PLCγ | +++ | +++ | +++ | ND | +++ | |
| Shc | +++ | +++ | ND | +++ | ++ | |
| SNT | ND | ND | +++ | +++ | ++ | |
| ERK1/2 | +++ | +++ | +++ | ND | +++ | |
| Other | +++† | |||||
| FGFR3 | ||||||
| PLCγ | +++ | +++ | ||||
| Shc | +++ | ++ | ||||
| SNT | +++ | +++ | ||||
| ERK1/2 | +++ | ++ | ||||
| Other | +++‡ | |||||
| FGFR4 | ||||||
| PLCγ | + | + | + | ++ | ||
| Shc | − | − | ND | ++ | ||
| SNT | ND | ND | − | ++ | ||
| ERK1/2 | + | − | + | + | ||
| Other | +++* | |||||
| Ref. | 7 | 8 | 9 | 10 | 11 | This study |
ND, not determined.
, p85; †, p80; ‡, p66.
