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Leptin fails to induce suppression of food intake in IL-1RI−/− mice. Leptin (4 μg/mouse, ICV) caused a highly significant (∗∗∗, P < 0.001 vs. vehicle) reduction in food intake over 22 h in C57BL/6 mice but had no effect in IL-1RI−/− mice that consumed a similar amount of food as the vehicle-treated animals (n = 6).
