Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effect of dosage of antisense PNA to the NTR (AS-NTR1) given i.p. on responses to NT (antinociception and hypothermia). Rats received varying doses of anti-NTR1 PNA injected i.p. (n ≥ 4 at each dose) and 24 hr later were microinjected with NT (18 nmol) into the PAG and scored for antinociception on the hot plate (%MPE) and for change in body temperature. ED50s were calculated by determining the effective dose (mg/kg) that gave 50% of the maximal response.
