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. 1999 Jun 22;96(13):7214–7219. doi: 10.1073/pnas.96.13.7214

Figure 1.

Figure 1

Sequence and expression pattern of NFAT5. (a) Predicted amino acid sequence of human NFAT5. The Rel homology region and a bipartite nuclear localization sequence are indicated by large and small boxes, respectively. Two polyglutamine stretches and a putative protein interaction motif (41) in the C-terminal region are singly and doubly underlined. (b) Schematic comparison of the five NFAT family members. Selected splice variants of NFAT1–4 are shown. The DNA-binding domain (DBD) conserved in NFAT1–5 and the regulatory domain (REG) represented in NFAT1–4 are indicated. TAD, transactivation domain. (c) Widespread expression of NFAT5 mRNA. The single NFAT5 transcript (≈13 kb) is expressed at highest levels in skeletal muscle, brain, heart, and peripheral blood leukocytes (PBL), and at moderate to detectable levels in other tissues. The blots were rehybridized with a human β-actin cDNA probe as a control for RNA loading.