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Rate constants of the intrinsic GTP, DABP-GTP hydrolysis reaction by various oncogenic Ras-proteins determined by HPLC
| Substrates/ Ras-proteins | GTP, min−1 | DABP-GTP, min−1 | DABP-GTP/GTP |
|---|---|---|---|
| Wild type | 0.019 | 0.18 | 10 |
| A12 | 0.0062 | ||
| V12 | 0.0043 | 3.1 | 720 |
| R12 | 0.0053 | 3.0 | 566 |
| A13 | 0.01 | 0.13 | 13 |
| A61 | 0.001 | 0.18 | 180 |
