Figure 1.

Full-length sequence of MMPDE10A. cDNA sequence of PDE10A is shown. Bold codons above the predicted start methionine are in-frame stop codons indicating the cDNA contains the entire ORF. Boxed amino acid regions indicate domains identified by sequence similarity to known domains in other proteins. Bold, italic amino acids in GAFA and GAFB domains correspond to residues thought to be important for the support of cGMP binding in PDE5. Top arrow points to the consensus motif [N(K/R)X_nFX₃DE] found in full in GAFB. Lower arrow points to a predicted bipartite nuclear localization signal found within the C terminus of PDE10A. Asterisk indicates the final stop codon.