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Effect of cGMP on cAMP hydrolysis and effect of cAMP on cGMP hydrolysis. [3H]cAMP hydrolysis was measured in the presence of 0.018 μM cAMP and a range of cGMP concentrations from 0.6 to 9.2 μM. The reverse also was done with [3H]cGMP (and 0.29 μM cGMP) and 0.052–0.6 μM cAMP. cAMP may function as a potent inhibitor of cGMP hydrolysis.
