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Inhibitor profile for PDE10A
| Inhibitor | Selective for PDE type (IC50) | IC50 for PDE10, μM (n = 3) |
|---|---|---|
| IBMX | Nonselective (2–50 μM) | 2.6 ± 0.6 |
| Zaprinast | PDE5/6 (0.76/0.15 μM) | 10.8 ± 1.4 |
| EHNA | PDE2 (1 μM) | 69 ± 2.8 |
| Enoximone | PDE3 (1 μM) | >100 |
| Dipyridamole | PDE5/6/8 (0.9/0.38/4.5 μM) | 1.1 ± 0.1 |
| SCH 51866 | PDE1 and 5/9 (0.1/1.5 μM) | 1 ± 0.3 |
| Sildenafil | PDE5 (3.9 nM) | >1 |
| Rolipram | PDE4 (2.0 μM) | 47.3 ± 8.2 |
