Snu13 is highly conserved from yeast to man. Sequences with high degrees of identity to budding yeast Snu13(sc) were found from Schizosaccharomyces pombe (Snu13sp), C. elegans (Snu13ce), and human (Snu13hs). Regions of homology also were found with budding yeast Nhp2. Sequences were aligned with the pileup program (GCG) and were aligned in boxshade (K. Hofman and M. Baron, Chemin des Boveresses, Lausanne, Switzerland). Identical amino acids are shaded black, with similar amino acids shaded gray.