Multiple sequence alignment of the deduced amino acid sequences of the 1Dx5*t, 1Dx5.1*t, 1Dx5 1Dx2.2*, 1Dx2.2, and 1Dx2 subunits. Alignments were assembled by eye to demonstrate the repeat structure of the central domains. Cysteine residues are highlighted by red shading. Deletions are indicated by dashes, The gray shading and box indicate differences and indels among 1Dx5*t, 1Dx5.1*t, and 1Dx5, respectively. The regions repeated directly in 1Dx2.2* and 1Dx2.2 are dark blue and light blue, respectively.