TABLE 2.
Phenotypic mutation rates
| Mutation rate (mutations/genome/generation)
|
|||
|---|---|---|---|
| Clone | α-FactorR (×10−6) | CanR (×10−7) | 5-FOAR (×10−8) |
| A | 5.51 (4.31–6.82) | 2.08 (1.67–2.51) | 6.49 (4.89–8.24) |
| B | 5.51 (4.31–6.81) | 1.81 (1.44–2.20) | 4.77 (3.53–6.15) |
| C | 6.28 (4.96–7.70) | 2.21 (1.77–2.69) | 7.19 (5.49–9.07) |
| D | 6.58 (5.23–8.04) | 1.88 (1.51–2.29) | 5.08 (3.73–6.58) |
| E | 5.60 (4.40–6.90) | 2.06 (1.66–2.50) | 4.48 (3.25–5.85) |
| F | 6.07 (4.81–7.44) | 1.87 (1.49–2.28) | 6.70 (5.10–8.45) |
| G | 5.35 (4.21–6.59) | 1.76 (1.41–2.14) | 4.74 (3.50–6.12) |
| H | 6.05 (4.79–7.42) | 2.05 (1.65–2.49) | 5.01 (3.69–6.47) |
| I | 6.00 (4.76–7.36) | 1.79 (1.43–2.17) | 7.03 (5.33–8.90) |
| J | 5.50 (4.35–6.76) | 2.09 (1.67–2.55) | 3.05 (2.11–4.11) |
| Average ± SD | 5.85 ± 0.41 | 1.96 ± 0.16 | 5.45 ± 1.34 |
| Combined | 5.86 (5.46–6.28) | 1.95 (1.83–2.08) | 5.43 (4.97–5.91) |
Mutation rates to α-factor resistance, canavanine resistance (CanR), and 5-fluoroorotic acid resistance (5-FOAR) for 10 clones of GIL104. Parentheses indicate the 95% confidence intervals calculated using Equations 29 and 30 from Foster (2006). The combined data set treats the 10 72-tube fluctuation assays as one 720-tube fluctuation assay.