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Model for CIN-4 role in centromere resolution and cohesin dynamics. A cartoon of a cross section of a mitotic chromosome (large circle). The majority of cohesin (shading) is removed by WAPL-1; however, a second population of cohesin near sister kinetochores is not removed by WAPL-1 (stippled oval). CIN-4 removes or reorganizes this second cohesin population to enable centromere resolution. Sister kinetochores are depicted as small solid circles.
