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. 2007 Nov 29;27(1):265–276. doi: 10.1038/sj.emboj.7601938

Figure 4.

Figure 4

Novel IGF-II mutations. (A) A view of the IGF-II/IGF2R-Dom11–13 complex with side chains investigated by mutagenesis shown as sticks and coloured according to the legend. (B) BIAcore analyses of IGF-II and analogues (representative curves each at 50 nM) binding to multi-domain IGF2R fragments. Curves are coloured as in the legend to panel A. (C) Summary of all IGF-II mutagenesis studies, which used IGF2R fragments. IGF-II side chains are coloured according to their effect on IGF2R binding (see legend).