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. 2007 Nov 29;27(1):265–276. doi: 10.1038/sj.emboj.7601938

Figure 7.

Figure 7

Evolutionary considerations. (A) Gain of IGF-II binding function. A surface view of IGF2R domain 11 and a ribbon view of bound IGF-II (magenta) are shown. IGF2R side chains identical across all species are coloured blue, while residues conserved across most species are coloured green. Side chains differing between monotremes and therian lineages, which are likely to be crucial in conferring IGF-II binding function are labelled and coloured gold. (B) Convergent evolution of IGF2R and the N-terminal domain of the IGFBPs towards binding the same region of the IGFs. The left panel shows a surface view of IGF2R domain 11, with bound IGF-II in magenta and Phe19 shown as yellow sticks. The right panel shows a surface view of the N-domain of IGFBP4, with bound IGF-I in blue and Phe16 shown as yellow sticks (PDB code 2DSQ).