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. 2007 Dec 6;27(1):88–99. doi: 10.1038/sj.emboj.7601954

Figure 6.

Figure 6

Model for the role of histone H3 modifications in the regulation of HP1 and 14-3-3 binding during transcriptional induction of the HDAC1 gene. In the transcriptional silent state, the HDAC1 promoter region is occupied by H3K9me2-modified nucleosomes and HP1γ. Activation of MAP kinase signaling via anisomycin and inhibition of HDAC activity via TSA leads to the formation of triple modified histone H3, stable binding of 14-3-3 and transcriptional induction of the HDAC1 gene. Removal of the phosphorylation and acetylation marks via phosphatases and deacetylases, respectively, can regenerate K9 dimethylated histone H3 and allow the re-association of HP1 proteins.