Table 1.

Molecular Adsorbent Recirculation System in acute on chronic liver failure

			Improvements
Study	Number	Controlled	Biochemical	CVS	CNS	Survival (30 days)a
Stange et al. [7]	13	No	Yes	N/A	Yes	69%
Schmidt et al. [10]	8	No	Yes	Yes	No	50%
Jalan et al. [37]	8	No	Yes	Yes	Yes	50%
Di Campli et al. [38]	13	No	Yes	N/A	Yes	38%
Mitzner et al. [8]	13	Yes	Yes	Yes	No	Yes (37.5% versus 0% at 7 days)
Heemann et al. [9]	23	Yes	Yes	Yes	Yes	Yes (90% versus 55%)
Sen et al. [11]	18	Yes	Yesb	No	Yes	No (45% in both)
Blei [16]	70	Yes	N/A	N/A	Yes	N/A
Laleman et al. [12]	18	Yes	Yesc	Yes	N/A	N/A

Biochemical improvements: statistically significant reduction in bilirubin, bile acids, creatinine, and ammonia. ^aPercentages indicate uncontrolled survival data; ^btrend did not reach statistical significance; ^cbilirubin and bile acids only. CNS, improvement in hemodynamic parameters (mean arterial pressure, heart rate, vasopressor requirements); CNS, decrease in hepatic encephalopathy grade (neurological improvement); N/A, not assessed.