Table 3.
Quality assessment of trials
| Reference | Sepsis criteria explicitly stateda | Volume challenge explicitly stated | Jadad and colleagues [9] score analysis |
| Tuchsmidt and colleagues [12] | Yes | Yesb | 1 |
| Peake and colleagues [10] | Yes | Yesc | 2 |
| Bollaert and colleagues [11] | Yes | No | 2 |
| Spapen and colleagues [19] | Yes | No | 2 |
| Alia and colleagues [18] | Yes | No | 1 |
| Boldt and colleagues [15] | Yes | No | 1 |
| Clark and colleagues [23] | Yes | No | 3 |
| Briegel and colleagues [17] | Yes | No | 2 |
| Rivers and colleagues [14] | Yes | Yesd | 3 |
| Cole and colleagues [13] | Yes | No | 1 |
| Emet and colleagues [16] | Yes | No | 2 |
| Bakker and colleagues [20] | Yes | No | 3 |
| Lopez and colleagues [21] | Yes | No | 2 |
aAmerican College of Chest Physicians/Society of Critical Care Medicine criteria [8]. b5% albumin in aliquots to achieve pulmonary artery occlusion pressure > 15 mmHg. c200 ml bolus over 15 minutes to achieve a sustained increase in pulmonary artery occlusion pressure ≥ 3 mmHg. d20–30 ml/kg initial fluid bolus over 1 hour followed by 500 ml every 30 minutes to achieve central venous pressure of 8–12 mmHg.