Table 1.

IGF-I mRNA levels

Tissue	mRNA
	LI-IGF-I −/−	Control
Brain	125  ±  20	100  ±  25
Kidney	80  ±  26	100  ±  38
Fat	136  ±  30	100  ±  25
Muscle	89  ±  18	100  ±  5
Spleen	38  ±  10**	100  ±  4
Liver	5  ±  1**	100  ±  9

Mice were induced with IFN at 24–28 days of age as described in the legend of Fig. 2. IGF-I mRNA levels in various tissues were measured by RNase-protection assay. The IGF-I mRNA expression was normalized to the level of 18S mRNA. Values are expressed as percent of control and are given as mean ± SEM. ∗∗, P < 0.01, LI-IGF-I −/− versus control (Student’s t test). Four or five animals were included in each group.