Table 3.

Dosing of opioids and sedative drugs at different time points

	Before intervention	n	After intervention	n	P value
Morphine
Day 1	0.54 ± 0.68	23	0.70 ± 0.85	38	0.55
Day 7	0.64 ± 0.99	11	0.49 ± 0.66	20	0.74
Day 14	0.53 ± 0.67	7	0.65 ± 0.72	8	0.90
Day 21	0.88 ± 0.78	3	0.06 ± 0.13	5	0.21
Day 28	0.25 ± 0.36	2	0.50 ± 0.81	3	0.67
Midazolam
Day 1	0.65 ± 1.0	23	0.84 ± 1.3	38	0.94
Day 7	0.82 ± 1.9	11	0.69 ± 1.8	20	0.80
Day 14	0.32 ± 0.58	7	1.7 ± 3.5	8	0.45
Day 21	0.40 ± 0.70	3	3.8 ± 8.6	5	0.42
Day 28	0.37 ± 0.52	2	6.0 ± 10.4	3	0.45
Propofol
Day 1	19.4 ± 35.3	23	13.5 ± 22.6	38	0.64
Day 7	3.0 ± 8.2	11	13.9 ± 29.8	20	0.49
Day 14	10.6 ± 27.8	7	21.8 ± 49.2	8	1.0
Day 21	24.6 ± 42.5	3	52.3 ± 97.6	5	0.60
Day 28	7.9 ± 11.2	2	32.0 ± 55.4	3	0.63

Data are presented in mg/kg per day as mean ± standard deviation. The P value was derived using the Student's t-test.