Table 5.
Sedative drugs for the whole period of 29 days
| Before intervention (n = 23) | After intervention (n = 38) | P value | |||
| Non-ALI/ARDS (n = 13) | ALI/ARDS (n = 10) | Non-ALI/ARDS (n = 23) | ALI/ARDS (n = 15) | ||
| Morphine | |||||
| Mean (mg/kg per day; 95% CI) | 0.18 (-0.33 to +0.69) | 0.61 (0.25 to 0.97) | 0.11 (-0.41 to +0.64) | 0.61 (0.33 to 0.90) | 0.18a |
| Patients needing morphine (n [%]) | 10 (77) | 7 (70) | 18 (78) | 14 (93) | 0.49b |
| Midazolam | |||||
| Mean (mg/kg per day; 95% CI) | 0.08 (-1.8 to +1.64) | 0.24 (-1.15 to +1.62) | 0.04 (-1.60 to +1.69) | 2.04 (0.93 to 3.15) | 0.08a |
| Patients needing midazolam (n [%]) | 8 (62) | 8 (80) | 10 (43) | 13 (87) | 0.04b |
| Propofol | |||||
| Mean (mg/kg per day; 95% CI) | 0.88 (-20.4 to +22.2) | 14.5 (-0.99 to +23.0) | 5.96 (-16.4 to +28.3) | 19.3 (7.12 to 31.5) | 0.44a |
| Patients needing propofol (n [%]) | 9 (69) | 9 (90) | 20 (87) | 14 (93) | 0.30b |
CI, confidence interval. aP value for comparison of means by linear mixed model analysis, comparing all four groups. bP value for comparison of number of patients by χ2 test. ALI, acute lung injury; ARDS, acute respiratory distress syndrome.