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HDAC inhibition induces neuritogenesis independently of cytoplasmic HDAC-6. RGC-5 cells were treated with 50 mM Na butyrate with and without RGC survival factors. Na butyrate is an HDAC inhibitor that does not inhibit cytoplasmic HDAC-6.13 Photomicrographs were taken at 200× magnification 24 hours after treatment. Neuritogenesis was seen, suggesting that HDAC inhibition differentiates RGC-5 cells by acting on nuclear HDACs. Scale bar, 50 μm.
