Fig. 1.
Gene structure and sequence comparison of zebrafish Hsp90α1 and Hsp90α2. (A) Zebrafish Hsp90α1 and Hsp90α2 share similar gene structures with 11 exons and 10 introns. Open boxes represent the 5′- and 3′-UTR regions. (B) Sequence comparison showing the region with more diverged sequences in Hsp90α1 and Hsp90α2 proteins. Sequence alignment indicates that zebrafish Hsp90α2 is more closely related to mouse and human Hsp90α. (C) MO antisense oligos and their target sequence in Hsp90α1 and Hsp90α2. The ATG start codon is identified in red. The intron sequences are shown in lowercase letters.