Table 1.
Summary of phospho-tyrosine profiling of 7 NSCLC cell lines
| Cell line | Mutation status of EGFR, KRAS | Gefitinib sensitivity (IC50, μM) | Phospho-peptides | Nonredundant phospho-proteins | Nonredundant phospho-peptides | Nonredundant phospho-sites |
|---|---|---|---|---|---|---|
| H358 | KRAS: G12V | ≈10 | 222 | 72 | 89 | 84 |
| H1650 | EGFR: E746-A750del | >10 | 321 | 180 | 251 | 220 |
| H1666 | EGFR: wt; KRAS: wt | ≈4 | 374 | 219 | 303 | 278 |
| H1734 | KRAS: G13C | >10 | 317 | 201 | 270 | 249 |
| H1975 | EGFR: L858R, T790M | >10 | 371 | 202 | 302 | 275 |
| HCC827 | EGFR: E746_A750del | <0.1 | 762 | 369 | 575 | 508 |
| H3255 | EGFR: L858R | <0.1 | 754 | 373 | 547 | 509 |