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. 2008 Jan 8;105(2):728–733. doi: 10.1073/pnas.0711018105

Table 2.

Summary of the neuroprotective genes and their human homologs

C. elegans gene ID Average % of worms with WT DA neurons* NCBI KOGs Relevance to H. sapiens
Blast E value % length
F32A6.3 (vps-41) 36.7 ± 5 Vacuolar assembly/sorting protein VSP41 5.1e−96 95.7
C35D10.2 31.5 ± 1 RGS–GAIP interacting protein GIPC 1.1e−49 75.4
M7.5 (atgr-7) 31.1 ± 1 Ubiquitin-activating E1 enzyme-like protein 7.4e−87 69.2
F16A11.2 24.8 ± 3 Uncharacterized conserved protein 1.2e−207 99.8
F55A4.1 23.7 ± 3 Synaptobrevin/VAMP-like protein SEC22 2.3e−47 96.3

*Compared with 12.8% with α-syn alone.

HHS Vulnerability Disclosure