Table 2.
Summary of the neuroprotective genes and their human homologs
C. elegans gene ID | Average % of worms with WT DA neurons* | NCBI KOGs | Relevance to H. sapiens |
|
---|---|---|---|---|
Blast E value | % length | |||
F32A6.3 (vps-41) | 36.7 ± 5 | Vacuolar assembly/sorting protein VSP41 | 5.1e−96 | 95.7 |
C35D10.2 | 31.5 ± 1 | RGS–GAIP interacting protein GIPC | 1.1e−49 | 75.4 |
M7.5 (atgr-7) | 31.1 ± 1 | Ubiquitin-activating E1 enzyme-like protein | 7.4e−87 | 69.2 |
F16A11.2 | 24.8 ± 3 | Uncharacterized conserved protein | 1.2e−207 | 99.8 |
F55A4.1 | 23.7 ± 3 | Synaptobrevin/VAMP-like protein SEC22 | 2.3e−47 | 96.3 |
*Compared with 12.8% with α-syn alone.