Fig. 4.

DISC is evoked by climbing fiber burst stimulation. (a) In voltage–clamp mode with a command potential of −55 mV, a climbing fiber was stimulated five times at 10 Hz, which produced a DISC-like inward current (CF-DISC). NBQX (0.5 μM) was subsequently added. (Calibration bar: 300 pA, 2 sec.) (b) CPCCOEt was bath-applied at t = 20 min. (Calibration bar: 200 pA, 2 sec.) (c) The average ratios of CF-DISC charge transfer (filled) and Δ noise SD (open) are plotted. The ratio reflects the value at t = 40 min/t = 20 min.