Figure 1.

Sequence alignment of human MKPs. (A) Domain organization of human MKP5. The MAP kinase binding domain (BD) and the catalytic domain (CD) are indicated. (B) Sequence alignment of human MKP5, MKP3, and MKP1. The secondary structure elements in MKP5 (S.S.) are labeled, and those in the NMR structure of the BD of MKP3 (Farooq et al. 2001) are shown at the bottom of the alignment. The start of the BD and CD are indicated in red. Residues not observed in our structures are shown in italic, and residues identical between MKP5 and MKP1 or MKP3 are shown in magenta.