Figure 1.

Structure of cC273. (A) Schematic view of the cC273 construct and its MPN core as well as the N- and C-terminal extensions in the context of the full-length C. elegans Prp8 (not drawn to proportion). (B) Overall structure of cC273 with secondary structures labeled. The structure is colored from blue to red in a rainbow spectrum from the N terminus to the C terminus. (C) Superimposition of the MPN domains of cC273 (blue) and Af2198 (yellow). The MPN domain is rotated 90° compared with B to best show the comparison. Labels 1–3 are examples of insertions that are much longer in cC273 than Af2198.