Figure 3.

Effect of glucocorticoid on the acute inflammatory response. The cellularity of the inflammatory exudate was measured in WT (white bars) or CRH KO (gray bars) mice treated either with sham adrenalectomy/corticosterone pellet supplementation (sham/cort) or with adrenalectomy/corticosterone pellet supplementation (adx/cort). Corticosterone administration to both WT and CRH KO mice, with or without adrenalectomy, significantly reduced (P < 0.05) the inflammatory response, compared with sham-adrenalectomized WT mice.