Relative contribution of CRH and epinephrine to the acute inflammatory response in WT mice. Cellularity of inflammatory exudates after administration of vehicle, CRH antagonist (CRH antag), propranolol (propr), or combination of both (CRH antag/propr). Although each agent alone inhibited the inflammatory response significantly, maximal inhibition was obtained by the combination of the two antagonists (P < 0.05, between all pairs).