Table 2.
Effect of Wilms' tumor 1 suppressor gene (WT1) plasmid with ZF - KTS on the growth of breast cancer cells
| Cells | pcDNA3 | pcDNA3/ZF - KTS | pcDNA3/WT1 | pSuper | pSuper/WT1 |
| MCF-7 | |||||
| Mean ± standard deviation (CFU) | 142 ± 3.3 | 51 ± 4* | 164 ± 9* | 51 ± 4.8 | 40 ± 3.7* |
| Relative change (%) | 0 | -64.1 | +15.5 | 0 | -21.8 |
| MDA468 | |||||
| Mean ± standard deviation (CFU) | 291 ± 8.7 | 214 ± 15.3* | 406 ± 17* | 177 ± 6.1 | 42 ± 1.7* |
| Relative change (%) | 0 | -26.5 | +39.5 | 0 | -76.2 |
| MDA231 | |||||
| Mean ± standard deviation (CFU) | 131 ± 6.2 | 130 ± 3.8 | 142 ± 5 | 36 ± 1.1 | 32 ± 3.0 |
| Relative change (%) | 0 | -0.2 | +8.8 | 0 | -11.2 |
Relative change represents the percentage difference in number of colony-forming units (CFU) produced in the zinc finger domain lacking the lysine–threonine–serine insert (ZF - KTS), in full-length WT1 or in WT1 shRNA transfected cells in comparison with empty vector, respectively. *P < 0.05.