Figure 5.

Network of functional association between CCL2 gene and other GATMs generated by Ingenuity database analysis. F3, F2R, F12, F10 and KNG1 are part of the complement and coagulation cascades. MMP12 encodes a matrix metalloproteinase involved in tissue remodelling. HBEGF and PGF encode growth factors. Associations with VEGF and KDR have been omitted for the sake of legibility. Genes are shown by their symbols. CCL, CC chemokine ligand; GATM, gene associated with mammary tumour microenvironment.